Alterations in the microenvironment of junctional epidermolysis bullosa keratinocytes: A gene expression study

Abstract excerpt

• JEB keratinocytes lacking either the integrin β4 subunit or type XVII collagen displayed similar dysregulation patterns of extracellular matrix(ECM) and focal adhesions(FAs)-associated genes, which is opposite in keratinocytes absent of the laminin β3 chain. • The hierarchy of stable adhesion in JEB keratinocytes follows the order of COL17- > ITGB4- > LAMB3-, aligning with the severity of their respective...