Article
Keratins and skin disease.
Cell and tissue research - 1 Jun 2015
Knöbel Maria, O'Toole Edel A, Smith Frances J D
Abstract excerpt
Mutations in keratin genes cause a diverse spectrum of skin, hair and mucosal disorders. Cutaneous disorders include epidermolysis bullosa simplex, palmoplantar keratoderma, epidermolytic ichthyosis and pachyonychia congenita. Both clinical and laboratory observations confirm a major role for keratins in maintaining epidermal cell-cell adhesion. When normal tissue homeostasis is disturbed, for example, during...
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