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Induced pluripotent stem cells in Parkinson's disease: scientific and clinical challenges

1 Feb 2016

Abstract excerpt

Induced pluripotent stem cells (iPSCs), which greatly circumvent the ethical issue of human embryonic stem cells (ESCs), can be induced to differentiate to dopaminergic (DA) neurons, and hence be used as a human disease model for Parkinson's disease (PD). iPSCs can be also utilised to probe the mechanism, and serve as an 'in vivo' platform for drug screening and for cell-replacement therapies. However, any...

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PMID: 26833176
DOI: 10.1136/jnnp-2015-312036

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