Article

DNA Circle-sequencing lowers the single molecule sequencing error threshold and identifies ultrasonication as a source of DNA damage

2025-07-31

Abstract excerpt

DNA mutation is the ultimate source of all heritable genetic and phenotypic variation. On human timescales, DNA mutation results in the evolution of antibiotic resistance, viral resistance to vaccines, the emergence human cancers, and more. Precise measurement of DNA mutation is therefore desirable to rapidly detect and analyze low frequency mutations in a population of cells. Precise measurement of DNA mutation b...

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Literature Corpus work: 72fa3b4b-51f8-548c-8a3c-7ca398f43067
DOI: 10.1101/2025.07.30.667586

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