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Spatial transcriptomic analysis of Sonic Hedgehog Medulloblastoma identifies that the loss of heterogeneity and promotion of differentiation underlies the response to CDK4/6 inhibition

2023-02-16

Abstract excerpt

<h4>Background</h4> Medulloblastoma (MB) is a malignant tumour of the cerebellum which can be classified into four major subgroups based on gene expression and genomic features. Single cell transcriptome studies have defined the cellular states underlying each MB subgroup, however the spatial organisation of these diverse cell states and how this impacts response to therapy remains to be determined. <h4>Methods</...

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Literature Corpus work
135aa493-79c3-5b70-97d8-17de6077fa79
DOI
10.1101/2023.02.15.528116
Open publication

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Spatial transcriptomic analysis of Sonic Hedgehog Medulloblastoma identifies that the loss of heterogeneity and promotion of differentiation underlies the response to CDK4/6 inhibitionDOI 10.1101/2023.02.15.528116
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