Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutations Inactivating Biosynthesis of Dispensable Carbohydrate-Antigens Prevented Extinctions in Primate/Human Lineage Evolution.

Journal of molecular evolution - 1 Apr 2025

Galili Uri

Abstract excerpt

The human natural anti-carbohydrate antibodies anti-Gal, anti-Neu5Gc, and anti-Forssman are "living-fossils" that appeared in ancestral apes, monkeys and hominins millions of years ago. These antibodies appeared at various evolutionary periods in few mutated-offspring that lost the ability to synthesize the corresponding dispensable (i.e., nonessential) carbohydrate-antigens, α-gal epitope, Neu5Gc (N-glycolyl...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens
Share to Biological Evolution
Share to Carbohydrates

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Evolution, Molecular

Share to Mutation

Share to Primates

Source

Identifiers

PMID: 40159432
DOI: 10.1007/s00239-025-10243-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutations Inactivating Biosynthesis of Dispensable Carbohydrate-Antigens Prevented Extinctions in Primate/Human Lineage Evolution.PMID 40159432Read ↗

Evolution in primates by “Catastrophic‐selection” interplay between enveloped virus epidemics, mutated genes of enzymes synthesizing carbohydrate antigens, and natural anti‐carbohydrate antibodiesSemantic proximity Read ↗

Human Natural Antibodies to Mammalian Carbohydrate Antigens as Unsung Heroes Protecting against Past, Present, and Future Viral InfectionsSemantic proximity Read ↗

Paleo‐immunology of human anti‐carbohydrate antibodies preventing primate extinctionsSemantic proximity Read ↗

Host Synthesized Carbohydrate Antigens on Viral Glycoproteins as “Achilles’ Heel” of Viruses Contributing to Anti-Viral Immune ProtectionSemantic proximity Read ↗

Absence of Neu5Gc and Presence of Anti-Neu5Gc Antibodies in Humans—An Evolutionary PerspectiveSemantic proximity Read ↗

Sexual selection by female immunity against paternal antigens can fix loss of function allelesSemantic proximity Read ↗

Evolution of sialic acids: Implications in xenotransplant biologySemantic proximity Read ↗

Loss of N-glycolylneuraminic acid in humans: Mechanisms, consequences, and implications for hominid evolution.Semantic proximity Read ↗

Evolution of Human-specific Alleles Protecting Cognitive Function of GrandmothersSemantic proximity Read ↗

Fondness for sugars of enteric viruses confronts them with human glycans genetic diversity.Semantic proximity Read ↗

Parallel evolution of a self-signal: humans and new world monkeys independently lost the cell surface sugar Neu5GcSemantic proximity Read ↗

Multiple Genomic Events Altering Hominin SIGLEC Biology and Innate Immunity Predated the Common Ancestor of Humans and Archaic Hominins.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.