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Article

Evolution of siglec-11 and siglec-16 genes in hominins.

Molecular biology and evolution - 1 Aug 2012

Wang Xiaoxia, Mitra Nivedita, Cruz Pedro, Deng Liwen, Varki Nissi, Angata Takashi, Green Eric D, Mullikin Jim, Hayakawa Toshiyuki, Varki Ajit

Abstract excerpt

We previously reported a human-specific gene conversion of SIGLEC11 by an adjacent paralogous pseudogene (SIGLEC16P), generating a uniquely human form of the Siglec-11 protein, which is expressed in the human brain. Here, we show that Siglec-11 is expressed exclusively in microglia in all human brains studied-a finding of potential relevance to brain evolution, as microglia modulate neuronal survival, and...

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Identifiers

PMID: 22383531
DOI: 10.1093/molbev/mss077
PMCID: PMC3408085

Genes

SIGLEC11

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