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Article

Multiple changes in sialic acid biology during human evolution.

Glycoconjugate journal - 1 Apr 2009

Varki Ajit

Abstract excerpt

Humans are genetically very similar to "great apes", (chimpanzees, bonobos, gorillas and orangutans), our closest evolutionary relatives. We have discovered multiple genetic and biochemical differences between humans and these other hominids, in relation to sialic acids and in Siglecs (Sia-recognizing Ig superfamily lectins). An inactivating mutation in the CMAH gene eliminated human expression of...

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Identifiers

PMID: 18777136
DOI: 10.1007/s10719-008-9183-z
PMCID: PMC7087641

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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