Article

Prediction of tumor-specific splicing from somatic mutations as a source of neoantigen candidates

2023-06-29

Abstract excerpt

Splicing is dysregulated in many tumors and may result in tumor-specific transcripts that can encode neoantigens, which are promising targets for cancer immunotherapy. Detecting tumor-specific splicing is challenging because many non-canonical splice junctions identified in tumor transcriptomes also appear in healthy tissues. Here, we developed splice2neo to integrate the predicted splice effects from somatic muta...

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Literature Corpus work: 84adb2ba-0344-594f-ba78-8a098debd698
DOI: 10.1101/2023.06.27.546494

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