Article

Targeting mitochondria mitigates chemotherapy-induced bone marrow dysfunction

2025-07-21

Abstract excerpt

<h4>Summary</h4> Chemotherapy has revolutionized cancer treatment but its long-term impact on healthy tissues, particularly the rapidly dividing hematopoietic system, remains a significant concern. We show that the chemotherapeutic agent 5-fluorouracil (5-FU) causes significant long-term defects of the hematopoietic system that mimics ageing, including myeloid lineage skewing and hematopoietic stem cell (HSC) dys...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 72e6f5bf-a669-5be4-b952-cfcba8baa17b
DOI: 10.1101/2025.07.18.665515

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Targeting mitochondria mitigates chemotherapy-induced bone marrow dysfunctionDOI 10.1101/2025.07.18.665515Read

Mitochondrial metabolism as a target for acute myeloid leukemia treatmentSemantic proximity Read

Understanding intrinsic hematopoietic stem cell agingSemantic proximity Read

Mitochondrial Contributions to Hematopoietic Stem Cell AgingSemantic proximity Read

Elevated mitochondrial membrane potential is a therapeutic vulnerability in Dnmt3a-mutant clonal hematopoiesis.Semantic proximity Read

Differentiation therapy for myeloid malignancies: beyond cytotoxicity.Semantic proximity Read

Induction of mitophagy reverts age-associated decline of the hematopoietic and immune systemsSemantic proximity Read

Imetelstat-Mediated Alterations in Fatty Acid Metabolism To Induce Ferroptosis As Therapeutic Strategy for Acute Myeloid LeukemiaSemantic proximity Read

CDK4/6 inhibition mitigates chemotherapy-induced expansion of TP53-mutant clonal hematopoiesis.Semantic proximity Read

The mitochondria as an emerging target of self-renewal in T-cell acute lymphoblastic leukemiaSemantic proximity Read

Mitochondrial abnormalities as a target of intervention in acute myeloid leukemiaSemantic proximity Read

The long-term effects of chemotherapy on normal blood cellsSemantic proximity Read

Antibiotics that target mitochondria effectively eradicate cancer stem cells, across multiple tumor types: Treating cancer like an infectious diseaseSemantic proximity Read