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Mitochondrial abnormalities as a target of intervention in acute myeloid leukemia

20 Jan 2025

Abstract excerpt

Acute myeloid leukemia (AML) is an aggressive hematological malignancy; it is the most common acute leukemia in adults. AML prognosis is often poor, and relapse often occurs after initial remission. Recurrent genetic abnormalities underlying this disease and the presence of leukemic stem cells complicate disease treatment. However, the complex metabolic reprogramming that enables the unrestrained cell growth seen...

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PMID: 39902131
DOI: 10.3389/fonc.2024.1532857

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