Article

Melatonin nanoparticles inhibit mutant hematopoiesis and restore bone marrow architecture in myeloproliferative neoplasms

2026-08-31

Abstract excerpt

Myeloproliferative neoplasms (MPN) are chronic hematologic malignancies characterized by clonal myeloid expansion, inflammation, oxidative stress, and progressive bone marrow (BM) remodeling that may culminate in fibrosis and secondary acute leukemia. Here, we evaluated the therapeutic efficacy and the underlying mechanisms of melatonin (MT) and liposomal melatonin (nano-MT) in preclinical MPN models. MT selective...

Identifiers and source

Literature Corpus work: 8ec1b080-c4c4-5743-b209-cf6cb1111eb1
DOI: 10.64898/2026.08.28.746520

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