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Article

Differentiation therapy for myeloid malignancies: beyond cytotoxicity.

Blood cancer journal - 4 Dec 2021

Stubbins Ryan J, Karsan Aly

Abstract excerpt

Blocked cellular differentiation is a central pathologic feature of the myeloid malignancies, myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). Treatment regimens promoting differentiation have resulted in incredible cure rates in certain AML subtypes, such as acute promyelocytic leukemia. Over the past several years, we have seen many new therapies for MDS/AML enter clinical practice, including...

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Share to Antineoplastic Agents
Share to Drug Discovery
Share to Epigenesis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hematopoiesis

Share to Leukemia, Myeloid, Acute

Share to Molecular Targeted Therapy

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Share to Myelodysplastic Syndromes

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Identifiers

PMID: 34864823
DOI: 10.1038/s41408-021-00584-3
PMCID: PMC8643352

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