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Mitochondrial Contributions to Hematopoietic Stem Cell Aging

15 Oct 2021

Abstract excerpt

Mitochondrial dysfunction and stem cell exhaustion are two hallmarks of aging. In the hematopoietic system, aging is linked to imbalanced immune response and reduced regenerative capacity in hematopoietic stem cells (HSCs), as well as an increased predisposition to a spectrum of diseases, including myelodysplastic syndrome and acute myeloid leukemia. Myeloid-biased differentiation and loss of polarity are...

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PMID: 34681777
DOI: 10.3390/ijms222011117

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