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Article

Unique phenotypic and T cell receptor characteristics of CD8+ T cells accumulated in the brains of Alzheimer's disease mice.

Scientific reports - 7 Mar 2026

Zhihuan Wang, Furusawa-Nishii Emi, Miyake Sachiko

Abstract excerpt

In Alzheimer’s disease (AD), the involvement of CD8⁺ tissue-resident memory T cells (Trm) have attracted growing interest. During AD pathogenesis, age-associated and AD-associated CD8⁺ T cells may cooperatively influence disease progression; however, their phenotypic and functional differences remain poorly understood. Here, we reanalyzed public single-cell RNA sequencing datasets of brain-derived CD8⁺ T cells...

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Identifiers

PMID: 41794902
DOI: 10.1038/s41598-026-38351-8
PMCID: PMC13087195

Genes

CXCR6

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