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Dietary Fiber and Microbiota Metabolite Receptors Enhance Cognition and Alleviate Disease in the 5xFAD Mouse Model of Alzheimer’s Disease

18 Aug 2023

Abstract excerpt

Alzheimer’s disease (AD) is a neurodegenerative disorder with poorly understood etiology. AD has several similarities with other “Western lifestyle” inflammatory diseases, where the gut microbiome and immune pathways have been associated. Previously, we and others have noted the involvement of metabolite-sensing GPCRs and their ligands, short-chain fatty acids (SCFAs), in protection of numerous Western diseases...

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PMID: 37596052
DOI: 10.1523/jneurosci.0724-23.2023

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