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Article

Heterogeneous resistance to colistin in Enterobacter cloacae complex due to a new small transmembrane protein

11 May 2019

Abstract excerpt

BACKGROUND: Enterobacter strains can display heterogeneous resistance (heteroresistance) to colistin but the mechanisms remain largely unknown. We investigated potential mechanisms of colistin heteroresistance in an Enterobacter clinical strain, WCHECl-1060, and found a new mechanism. METHODS: Strain WCHECl-1060 was subjected to WGS to identify known colistin resistance mechanisms. Tn5 insertional mutagenesis,...

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PMID: 31169899
DOI: 10.1093/jac/dkz236

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