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Article

Study of the mechanisms of colistin heteroresistance in a strain of Enterobacter cloacae by random mutagenesis.

Journal of global antimicrobial resistance - 1 Dec 2024

Milleville Romane, Hadjadj Linda, Rolain Jean-Marc, Baron Sophie Alexandra

Abstract excerpt

OBJECTIVE: The Enterobacter cloacae complex belongs to a group in which colistin resistance is not well documented due to their frequent heteroresistance. METHODS: We investigated the molecular basis of colistin heteroresistance using genome analysis and random mutagenesis in a strain of E. cloacae. RESULTS: The arnA gene was truncated in the six colistin susceptible mutants we obtained. However, the mcr-9 gene...

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Identifiers

PMID: 39486688
DOI: 10.1016/j.jgar.2024.10.260

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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