Article

GPR37 Processing and Density in Neurodegeneration: A Potential Marker for Parkinson’s Disease Progression Rate

2024-02-07

Abstract excerpt

<h4>Background: </h4> The orphan G protein-coupled receptor 37 (GPR37), widely associated with Parkinson's disease (PD), undergoes proteolytic processing under physiological conditions. The N-terminus domain is proteolyzed by a disintegrin and metalloproteinase 10 (ADAM-10), which generates various membrane receptor forms and ectodoamin shedding (ecto-GPR37) in the extracellular environment. <h4>Methods: </h4> We...

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Literature Corpus work: 72854abb-9edb-5935-8617-9dec74380d0c
DOI: 10.21203/rs.3.rs-3917369/v1

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