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Article

Plasma Small Extracellular Vesicle Cathepsin D Dysregulation in GRN/C9orf72 and Sporadic Frontotemporal Lobar Degeneration.

International journal of molecular sciences - 14 Sept 2022

Bellini Sonia, Saraceno Claudia, Benussi Luisa, Geviti Andrea, Longobardi Antonio, Nicsanu Roland, Cimini Sara, Ricci Martina, Canafoglia Laura, Coppola Cinzia, Puoti Gianfranco, Binetti Giuliano, Rossi Giacomina, Ghidoni Roberta

Abstract excerpt

Emerging data suggest the roles of endo-lysosomal dysfunctions in frontotemporal lobar degeneration (FTLD) and in other dementias. Cathepsin D is one of the major lysosomal proteases, mediating the degradation of unfolded protein aggregates. In this retrospective study, we investigated cathepsin D levels in human plasma and in the plasma small extracellular vesicles (sEVs) of 161 subjects (40 sporadic FTLD, 33...

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Identifiers

PMID: 36142612
DOI: 10.3390/ijms231810693
PMCID: PMC9504770

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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