Article

Selective targeting of the oligodendroglial GPR17 receptor improves myelin integrity and motor function in female SOD1 <sup>G93A</sup> mice

2026-04-30

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with no definitive disease-modifying therapies available, underscoring the urgent need to identify novel druggable targets. The G protein-coupled receptor GPR17 is a critical regulator of oligodendrocyte maturation and has emerged as a candidate target in ALS, yet its relevance to human disease and its therapeutic potential remain unclear. He...

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Literature Corpus work: 55a845f8-c98c-5282-ba64-7ba38ad39f9d
DOI: 10.64898/2026.04.28.721299

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