Article

Investigating the role of the secreted tumour suppressor Dickkopf-3 in stromal-epithelial interactions in prostate cancer

2018-01-01

Abstract excerpt

DKK3 is a tumour suppressor gene encoding a secreted protein, Dkk-3, which is found in benign prostate and prostate cancer stroma. Dkk-3 maintains normal prostate epithelial acinar morphogenesis by limiting TGF-β/Smad/matrix metalloproteinase signalling. The role of stromal Dkk-3 was investigated in this thesis. The human prostate stromal cell line, WPMY-1, secreted a high level of Dkk-3 that was further increased...

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Literature Corpus work: 7274d689-018f-55b6-899c-d1cb1d210da1
DOI: 10.25560/58103

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