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Article

ERK5 signalling in prostate cancer promotes an invasive phenotype.

British journal of cancer - 15 Feb 2011

Ramsay A K, McCracken S R C, Soofi M, Fleming J, Yu A X, Ahmad I, Morland R, Machesky L, Nixon C, Edwards D R, Nuttall R K, Seywright M, Marquez R, Keller E, Leung H Y

Abstract excerpt

BACKGROUND: Aberrant mitogen/extracellular signal-regulated kinase 5 (MEK5)-extracellular signal-regulated protein kinase 5 (ERK5)-mediated signalling has been implicated in a number of tumour types including prostate cancer (PCa). The molecular basis of ERK5-driven carcinogenesis and its clinical relevance remain to be fully characterised. METHODS: Modulation of ERK5 expression or function in human PCa PC3 and...

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Identifiers

PMID: 21266977
DOI: 10.1038/sj.bjc.6606062
PMCID: PMC3049582

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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