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Article

Dickkopf1: A tumor suppressor or metastasis promoter?

27 Sept 2011

Abstract excerpt

Dickkopf1 (DKK1), a secreted inhibitor of the Wnt/β-catenin pathway, is a negative regulator of bone formation. DKK1 acts as a switch that transitions prostate cancer bone metastases from osteolytic to osteoblastic and also is an active indicator of poor outcome for multiple myeloma. However, in other tumor types, DKK1 upregulation or overexpression suppresses tumor growth. Thus, the role of DKK1 in cancer...

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PMID: 21953410
DOI: 10.1002/ijc.26449

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