Article
Persistent inflammation leads to proliferative neoplasia and loss of smooth muscle cells in a prostate tumor model.
Neoplasia (New York, N.Y.) - 1 Aug 2011
Birbach Andreas, Eisenbarth David, Kozakowski Nicolas, Ladenhauf Eva, Schmidt-Supprian Marc, Schmid Johannes A
Abstract excerpt
In prostate cancers, epidemiological data suggest a link between prostate inflammation and subsequent cancer development, but proof for this concept in a tumor model is lacking. A constitutively active version of IκB kinase 2 (IKK2), which is activated by many inflammatory stimuli, was expressed specifically in the prostate epithelium. Constitutive activation of the IKK2/nuclear factor κB axis was insufficient...
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