Article
CRISP3 expression drives prostate cancer invasion and progression.
Endocrine-related cancer - 1 Jul 2020
Volpert Marianna, Furic Luc, Hu Jinghua, O'Connor Anne E, Rebello Richard J, Keerthikumar Shivakumar, Evans Jemma, Merriner D Jo, Pedersen John, Risbridger Gail P, McIntyre Peter, O'Bryan Moira K
Abstract excerpt
Identifying the factors stimulating prostate cancer cells migration and invasion has the potential to bring new therapeutic targets to the clinic. Cysteine-rich secretory protein 3 (CRISP3) is one of the most highly upregulated proteins during the transition of a healthy human prostatic epithelium to prostate cancer. Here we show using a genetically engineered mouse model of prostate cancer that CRISP3 production...
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