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Article

Virulence of Enterovirus A71 Fluctuates Depending on the Phylogenetic Clade Formed in the Epidemic Year and Epidemic Region.

Journal of virology - 9 Nov 2021

Kobayashi Kyousuke, Nishimura Hidekazu, Mizuta Katsumi, Nishizawa Tomoha, Chu Son T, Ichimura Hiroshi, Koike Satoshi

Abstract excerpt

Although epidemics of hand, foot, and mouth disease (HFMD) caused by enterovirus A71 (EV-A71) have occurred worldwide, the Asia-Pacific region has seen large sporadic outbreaks with many severe neurological cases. This suggests that the virulence of the circulating viruses fluctuates in each epidemic and that HFMD outbreaks with many severe cases occur when highly virulent viruses are circulating predominantly,...

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PMID: 34523967
DOI: 10.1128/JVI.01515-21
PMCID: PMC8577370

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