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Article

VP1 residues around the five-fold axis of enterovirus A71 mediate heparan sulfate interaction.

Virology - 15 Jan 2017

Tan Chee Wah, Sam I-Ching, Lee Vannajan Sanghiran, Wong Hui Vern, Chan Yoke Fun

Abstract excerpt

Enterovirus A71 (EV-A71) is a neurotropic enterovirus that uses heparan sulfate as an attachment receptor. The molecular determinants of EV-A71-heparan sulfate interaction are unknown. With In silico heparin docking and mutagenesis of all possible lysine residues in VP1, we identified that K162, K242 and K244 are responsible for heparin interaction and inhibition. EV-A71 mutants with K242A and K244A rapidly...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27875780
DOI: 10.1016/j.virol.2016.11.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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