Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Selective Bottleneck Shapes the Evolutionary Mutant Spectra of Enterovirus A71 during Viral Dissemination in Humans.

Journal of virology - 1 Dec 2017

Huang Sheng-Wen, Huang Yi-Hui, Tsai Huey-Pin, Kuo Pin-Hwa, Wang Shih-Min, Liu Ching-Chuan, Wang Jen-Ren

Abstract excerpt

RNA viruses accumulate mutations to rapidly adapt to environmental changes. Enterovirus A71 (EV-A71) causes various clinical manifestations with occasional severe neurological complications. However, the mechanism by which EV-A71 evolves within the human body is unclear. Utilizing deep sequencing and haplotype analyses of viruses from various tissues of an autopsy patient, we sought to define the evolutionary...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Capsid Proteins
Share to Central Nervous System

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enterovirus A, Human

Share to Enterovirus Infections

Share to Gastrointestinal Tract

Share to Plasma

Share to Quasispecies

Share to Respiratory System

Source

Open in PubMed Open full text

Identifiers

PMID: 28931688
DOI: 10.1128/JVI.01062-17
PMCID: PMC5686718

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Selective Bottleneck Shapes the Evolutionary Mutant Spectra of Enterovirus A71 during Viral Dissemination in Humans.PMID 28931688Read ↗

Enterovirus A71: virulence, antigenicity, and genetic evolution over the yearsSemantic proximity Read ↗

Evolutionary Genetics of Human Enterovirus 71: Origin, Population Dynamics, Natural Selection, and Seasonal Periodicity of the VP1 GeneSemantic proximity Read ↗

Genomic Epidemiology and Phylodynamic Analysis of Enterovirus A71 Reveal Its Transmission Dynamics in AsiaSemantic proximity Read ↗

Evolution of re-emergent virus and its impact on enterovirus 71 epidemics.Semantic proximity Read ↗

Mutations in the non-structural protein region contribute to intra-genotypic evolution of enterovirus 71.Semantic proximity Read ↗

Genetic evolution of Human Enterovirus A71 subgenotype C4 in Shenzhen, China, 1998-2013.Semantic proximity Read ↗

Impact of Genomic Variations Found in Enterovirus A71 Virus Population on Viral Properties and Disease Severity.Semantic proximity Read ↗

Viral determinants that drive Enterovirus-A71 fitness and virulence.Semantic proximity Read ↗

Identification of site-specific adaptations conferring increased neural cell tropism during human enterovirus 71 infection.Semantic proximity Read ↗

Amino acid variation at VP1-145 of enterovirus A71 determines the viral infectivity and receptor usage in a primary human intestinal modelSemantic proximity Read ↗

Mutation of the highly conserved amino acids in the N-terminal region of the EV-A71 VP1 protein impairs viral RNA release during virus entry.Semantic proximity Read ↗

Changes in the EV-A71 Genome through Recombination and Spontaneous Mutations: Impact on Virulence.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.