Article
Electrostatic interactions at the five-fold axis alter heparin-binding phenotype and drive enterovirus A71 virulence in mice.
PLoS pathogens - 1 Nov 2019
Tee Han Kang, Tan Chee Wah, Yogarajah Thinesshwary, Lee Michelle Hui Pheng, Chai Hann Juang, Hanapi Nur Aziah, Yusof Siti R, Ong Kien Chai, Lee Vannajan Sanghiran, Sam I-Ching, Chan Yoke Fun
Abstract excerpt
Enterovirus A71 (EV-A71) causes hand, foot and mouth disease epidemics with neurological complications and fatalities. However, the neuropathogenesis of EV-A71 remains poorly understood. In mice, adaptation and virulence determinants have been mapped to mutations at VP2-149, VP1-145 and VP1-244. We investigate how these amino acids alter heparin-binding phenotype and shapes EV-A71 virulence in one-day old mice....
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