Article
A Single Mutation in the VP1 Gene of Enterovirus 71 Enhances Viral Binding to Heparan Sulfate and Impairs Viral Pathogenicity in Mice.
Viruses - 13 Aug 2020
Ke Xianliang, Zhang Yuan, Liu Yan, Miao Yuanjiu, Zheng Caishang, Luo Dan, Sun Jianhong, Hu Qinxue, Xu Yi, Wang Hanzhong, Zheng Zhenhua
Abstract excerpt
Enterovirus 71 (EV71) is the major causative pathogen of human hand, foot, and mouth disease (hHFMD) and has evolved to use various cellular receptors for infection. However, the relationship between receptor preference and EV71 virulence has not been fully revealed. By using reverse genetics, we identified that a single E98K mutation in VP1 is responsible for rapid viral replication in vitro. The E98K mutation...
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