Article
Role of AMP--activated protein kinase in the control of glucose homeostasis.
Current molecular medicine - 1 May 2005
Barnes B R, Zierath J R
Abstract excerpt
Skeletal muscle insulin resistance is a hallmark feature of Type 2 diabetes. Physical exercise/muscle contraction elicits an insulin-independent increase in glucose transport and perturbation of this pathway may bypass defective insulin signaling. To date, the exercise-responsive signaling molecules governing glucose metabolism in skeletal muscle are largely unknown. AMP-activated protein kinase (AMPK) has been...
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