Article

The human AMPKγ3 R225W mutation does neither enhance basal AMPKγ3-associated activity nor glycogen in human or mouse skeletal muscle

2023-08-28

Abstract excerpt

<h4>Background</h4> AMP-activated protein kinase (AMPK) is activated during cellular energy perturbation. AMPK is composed of three subunits and several variants of AMPK complexes are expressed in skeletal muscle. The regulatory AMPKγ3 subunit is predominantly expressed in fast-twitch muscle fibers. A human AMPKγ3 R225W mutation has been described in two families. In cultured cells derived from R225W carrier musc...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 376517ab-442e-5e8b-8271-dbeaf5ce65c1
DOI: 10.1101/2023.08.28.555048

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The human AMPKγ3 R225W mutation does neither enhance basal AMPKγ3-associated activity nor glycogen in human or mouse skeletal muscleDOI 10.1101/2023.08.28.555048Read

The human AMPKγ3 R225W mutation negatively impacts site-1 nucleotide binding and does not enhance basal AMPKγ3-associated activity nor glycogen production in human or mouse skeletal muscle.Semantic proximity Read

Gain-of-function R225W mutation in human AMPKgamma(3) causing increased glycogen and decreased triglyceride in skeletal muscle.Semantic proximity Read

Cloning and characterization of mouse 5'-AMP-activated protein kinase gamma3 subunit.Semantic proximity Read

Muscle-specific overexpression of wild type and R225Q mutant AMP-activated protein kinase gamma3-subunit differentially regulates glycogen accumulation.Semantic proximity Read

Gain of function AMP-activated protein kinase γ3 mutation (AMPKγ3R200Q) in pig muscle increases glycogen storage regardless of AMPK activation.Semantic proximity Read

Metabolic functions of AMPK: aspects of structure and of natural mutations in the regulatory gamma subunits.Semantic proximity Read

Naturally occurring R225W mutation of the gene encoding AMP-activated protein kinase (AMPK)gamma(3) results in increased oxidative capacity and glucose uptake in human primary myotubes.Semantic proximity Read

Opposite transcriptional regulation in skeletal muscle of AMP-activated protein kinase gamma3 R225Q transgenic versus knock-out mice.Semantic proximity Read

5'-AMP-activated protein kinase regulates skeletal muscle glycogen content and ergogenics.Semantic proximity Read

Human γ2-AMPK Mutations.Semantic proximity Read

Common and distinct roles of AMPKγ isoforms in small-molecule activator-stimulated glucose uptake in mouse skeletal muscleSemantic proximity Read

Ampk alpha2 T172 Activation Dictates Exercise Performance and Energy Transduction in Skeletal MuscleSemantic proximity Read