Article

Evolutionary implications of phenotype switching for growth and survival of tumors in stochastic environments.

2026-08-22

Abstract excerpt

Tumors evolve under constantly changing microenvironmental conditions, and a key major mechanism by which cancer cells adapt to fluctuating environments is stochastic phenotypic switch via epithelial-mesenchymal plasticity (EMP). Here we demonstrate the existence of EMP in human breast epithelial cell lines and assess the fitness of E and M cells in environments that fluctuate between favorable and harsh condition...

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Identifiers and source

Literature Corpus work: 72429b2b-0765-581c-b30d-071fd80e0528
DOI: 10.64898/2026.08.18.745434

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