Modeling stress-induced responses: plasticity in continuous state space and gradual clonal evolution.

Abstract excerpt

Mathematical models of cancer and bacterial evolution have generally stemmed from a gene-centric framework, assuming clonal evolution via acquisition of resistance-conferring mutations and selection of their corresponding subpopulations. More recently, the role of phenotypic plasticity has been recognized and models accounting for phenotypic switching between discrete cell states (e.g., epithelial and...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Adaptation, Physiological
• Share to Biological Evolution
• Share to Clonal Evolution