Article
From driver genes to gene families: A computational analysis of oncogenic mutations and ubiquitination anomalies in hepatocellular carcinoma.
Computational biology and chemistry - 1 Oct 2024
Wang Meng, Yan Xinyue, Dong Yanan, Li Xiaoqin, Gao Bin
Abstract excerpt
Hepatocellular carcinoma (HCC) is a widespread primary liver cancer with a high fatality rate. Despite several genes with oncogenic effects in HCC have been identified, many remain undiscovered. In this study, we conducted a comprehensive computational analysis to explore the involvement of genes within the same families as known driver genes in HCC. Specifically, we expanded the concept beyond single-gene...
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