Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Integrated Genomic Analysis of the Ubiquitin Pathway across Cancer Types

1 Apr 2018

Abstract excerpt

Protein ubiquitination is a dynamic and reversible process of adding single ubiquitin molecules or various ubiquitin chains to target proteins. Here, using multidimensional omic data of 9,125 tumor samples across 33 cancer types from The Cancer Genome Atlas, we perform comprehensive molecular characterization of 929 ubiquitin-related genes and 95 deubiquitinase genes. Among them, we systematically identify top...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Epigenetics and DNA Methylation
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29617661
DOI: 10.1016/j.celrep.2018.03.047

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Integrated Genomic Analysis of the Ubiquitin Pathway across Cancer TypesPMID 29617661Read ↗

Ubiquitination in cancer: mechanisms and therapeutic opportunitiesSemantic proximity Read ↗

Ubiquitin becomes ubiquitous in cancerSemantic proximity Read ↗

Bioinformatics-based pan-cancer analysis of UBE2CSemantic proximity Read ↗

A portrayal of E3 ubiquitin ligases and deubiquitylases in cancerSemantic proximity Read ↗

A Comprehensive Assessment of Genetic and Epigenetic Alterations Identifies Frequent Variations Impacting Six Prototypic SCF Complex Members.Semantic proximity Read ↗

FBXW7 and the Hallmarks of Cancer: Underlying Mechanisms and Prospective StrategiesSemantic proximity Read ↗

A pan-cancer analysis of USP5: its diagnostic, prognostic and immunological roles in human cancersSemantic proximity Read ↗

The FBXW7-NOTCH interactome: A ubiquitin proteasomal system-induced crosstalk modulating oncogenic transformation in human tissues.Semantic proximity Read ↗

Molecular insights and clinical implications for the tumor suppressor role of SCFFBXW7 E3 ubiquitin ligaseSemantic proximity Read ↗

A pan-cancer analysis of the role of USP5 in human cancersSemantic proximity Read ↗

Role of the ubiquitin ligase Fbw7 in cancer progression.Semantic proximity Read ↗

Ubiquitin-conjugating enzyme 2C (UBE2C) plays as a cancer diagnostic and prognostic marker: A Bioinformatics pan-cancer analysisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.