Article

PARP Inhibition Modulates Mitochondrial Morphology and Metabolism Under Hypoxic Stress in Cancer Cells

2025-09-12

Abstract excerpt

<title>Abstract</title> <p>Hypoxia, low oxygen availability, is one of the main factors that determine tumor growth and metastasis survival. The hypoxic response is orchestrated by HIF factors which guide an array of genetic and metabolic adaptations that promote angiogenesis, metabolic reprogramming or migration, and finally a clinically malignant phenotype. Mitochondria play a crucial role during hypoxia, as th...

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Literature Corpus work: 724111cc-4455-5a1d-bca3-53c5d16a4815
DOI: 10.21203/rs.3.rs-7363618/v1

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