Tumors defective in homologous recombination rely on oxidative metabolism: relevance to treatments with PARP inhibitors

Abstract excerpt

Abstract Mitochondrial metabolism and the generation of reactive oxygen species (ROS) contribute to the acquisition of DNA mutations and genomic instability in cancer. How genomic instability influences the metabolic capacity of cancer cells is nevertheless poorly understood. Here, we show that homologous recombination‐defective (HRD) cancers rely on oxidative metabolism to supply NAD + and ATP for...

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