Article
Metabolic profiling of hypoxic cells revealed a catabolic signature required for cell survival.
PloS one - 1 Jan 2011
Frezza Christian, Zheng Liang, Tennant Daniel A, Papkovsky Dmitri B, Hedley Barbara A, Kalna Gabriela, Watson David G, Gottlieb Eyal
Abstract excerpt
Hypoxia is one of the features of poorly vascularised areas of solid tumours but cancer cells can survive in these areas despite the low oxygen tension. The adaptation to hypoxia requires both biochemical and genetic responses that culminate in a metabolic rearrangement to counter-balance the decrease in energy supply from mitochondrial respiration. The understanding of metabolic adaptations under hypoxia could...
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