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Article

Mitochondrial superoxide sustains a senescence-like phenotype in PARP- inhibited ovarian cancer cells by stabilizing HIF1α.

Redox biology - 1 Jun 2026

Yang Tingting, Bu Wenqing, Xue Xiaotong, Wu Xuemin, Zhou Yipeng, Chen Yue, Li Yanan, Zhang Jia, Li Peishan, Shen Fangrong, Shi Yufang, Shao Changshun

Abstract excerpt

Ovarian cancer is the deadliest gynecological malignant tumor and is known as the "silent killer". PARP inhibitors are being increasingly used for their excellent efficacy in the treatment of ovarian cancer. While PARP inhibitors are known to interfere with DNA repair and cause DNA damage, the fates of cancer cells and associated metabolic features in response to PARP inhibition are not well characterized. We...

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Identifiers

PMID: 41980461
DOI: 10.1016/j.redox.2026.104158
PMCID: PMC13092849

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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