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Article

Hypoxic enlarged mitochondria protect cancer cells from apoptotic stimuli.

Journal of cellular physiology - 1 Mar 2010

Chiche Johanna, Rouleau Matthieu, Gounon Pierre, Brahimi-Horn M Christiane, Pouysségur Jacques, Mazure Nathalie M

Abstract excerpt

It is well established that cells exposed to the limiting oxygen microenvironment (hypoxia) of tumors acquire resistance to chemotherapy, through mechanisms not fully understood. We noted that a large number of cell lines showed protection from apoptotic stimuli, staurosporine, or etoposide, when exposed to long-term hypoxia (72 h). In addition, these cells had unusual enlarged mitochondria that were induced in a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19957303
DOI: 10.1002/jcp.21984

Genes

BNIP3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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