Article
DNA methylome of familial breast cancer identifies distinct profiles defined by mutation status.
American journal of human genetics - 12 Mar 2010
Flanagan James M, Cocciardi Sibylle, Waddell Nic, Johnstone Cameron N, Marsh Anna, Henderson Stephen, Simpson Peter, da Silva Leonard, Khanna Kumkum, Lakhani Sunil, Boshoff Chris, Chenevix-Trench Georgia
Abstract excerpt
It is now understood that epigenetic alterations occur frequently in sporadic breast carcinogenesis, but little is known about the epigenetic alterations associated with familial breast tumors. We performed genome-wide DNA-methylation profiling on familial breast cancers (n = 33) to identify patterns of methylation specific to the different mutation groups (BRCA1, BRCA2, and BRCAx) or intrinsic subtypes of breast...
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