Article

Endothelial Expression of Beta‐1 Integrin Is Required for Embryonic Vascular Patterning and Postnatal Vascular Remodeling

2008-03-01

Abstract excerpt

The largest subgroup of integrins is that containing the β1 subunit. Global deletion of β1 integrin expression results in embryonic lethality at ~E5, a developmental time point too early to determine the effects of this integrin on vascular development. To elucidate the specific role of β1 integrin in the vasculature, we conditionally deleted the β1 gene in the endothelium using Cre/LoxP techniques. Homozygous del...

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Literature Corpus work: 722d6667-b003-520d-83c1-7deca0d1a718
DOI: 10.1096/fasebj.22.1_supplement.1122.11

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