Article

PRDM3 attenuates pancreatitis and pancreatic tumorigenesis by regulating inflammatory response

2019-12-23

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) is associated with metaplastic changes in the pancreas but the transcriptional program underlying these changes is incompletely understood. The zinc finger transcription factor, PRDM3, is lowly expressed in normal pancreatic acini and its expression increases during tumorigenesis. Although PRDM3 promotes proliferation and migration of PDAC cell lines, the role of PRDM3 durin...

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Identifiers and source

Literature Corpus work: 72181b9a-76d4-523e-8452-484dad6975bb
DOI: 10.1101/2019.12.18.880823

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