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Article

Activating transcription factor 3 promotes loss of the acinar cell phenotype in response to cerulein-induced pancreatitis in mice.

Molecular biology of the cell - 1 Sept 2017

Fazio Elena N, Young Claire C, Toma Jelena, Levy Michael, Berger Kurt R, Johnson Charis L, Mehmood Rashid, Swan Patrick, Chu Alphonse, Cregan Sean P, Dilworth F Jeffrey, Howlett Christopher J, Pin Christopher L

Abstract excerpt

Pancreatitis is a debilitating disease of the exocrine pancreas that, under chronic conditions, is a major susceptibility factor for pancreatic ductal adenocarcinoma (PDAC). Although down-regulation of genes that promote the mature acinar cell fate is required to reduce injury associated with pancreatitis, the factors that promote this repression are unknown. Activating transcription factor 3 (ATF3) is a key...

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Share to Acinar Cells
Share to Carcinoma, Pancreatic Ductal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28701342
DOI: 10.1091/mbc.E17-04-0254
PMCID: PMC5576899

Genes

ATF3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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