Article

Structure-guided disulfide engineering restricts antibody conformation and flexibility to elicit TNFR agonism

2024-08-04

Abstract excerpt

<title>Abstract</title> <p>A promising strategy in cancer immunotherapy is activation of immune signalling pathways through antibodies that target co-stimulatory receptors. hIgG2, one of four human antibody isotypes, is known to deliver strong agonistic activity, and modification of hIgG2 hinge disulfides can influence immune-stimulating activity. This was shown for antibodies directed against the hCD40 receptor,...

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Literature Corpus work: 7210f73a-b1a0-5cb3-ad97-5f9e69686961
DOI: 10.21203/rs.3.rs-4790930/v1

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