Article

Facile generation of biepitopic antibodies with intrinsic agonism for activating receptors in the tumor necrosis factor superfamily

2023-12-12

Abstract excerpt

<h4>Summary</h4> Agonist antibodies that activate cellular receptors are being pursued for therapeutic applications ranging from neurodegenerative diseases to cancer. For the tumor necrosis factor (TNF) receptor superfamily, higher-order clustering of three or more receptors is key to their potent activation. This can be achieved using antibodies that recognize two unique epitopes on the same receptor and mediate...

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Literature Corpus work: 1609d9a3-20f7-540d-9b56-8657ab3c3d1e
DOI: 10.1101/2023.12.11.571146

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