Article
Anti-inflammatory activity of human IgG4 antibodies by dynamic Fab arm exchange.
Science (New York, N.Y.) - 14 Sept 2007
van der Neut Kolfschoten Marijn, Schuurman Janine, Losen Mario, Bleeker Wim K, Martínez-Martínez Pilar, Vermeulen Ellen, den Bleker Tamara H, Wiegman Luus, Vink Tom, Aarden Lucien A, De Baets Marc H, van de Winkel Jan G J, Aalberse Rob C, Parren Paul W H I
Abstract excerpt
Antibodies play a central role in immunity by forming an interface with the innate immune system and, typically, mediate proinflammatory activity. We describe a novel posttranslational modification that leads to anti-inflammatory activity of antibodies of immunoglobulin G, isotype 4 (IgG4). IgG4 antibodies are dynamic molecules that exchange Fab arms by swapping a heavy chain and attached light chain...
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