Article

Targeting the gene encoding human T-cell leukemia virus type 1 basic zip factor via CRISPR/Cas9 potentially mitigates viral infection

2025-08-27

Abstract excerpt

<title>Abstract</title> Herein, we investigated the role of an essential transcription factor in the human T-cell leukemia virus type 1 (HTLV-1) provirus, the HTLV-1 basic zip factor (HBZ), in HTLV-1 infections and adult T-cell leukemia/lymphoma (ATL). We designed five synthetic guide RNAs (sgRNAs) targeting <italic>HBZ</italic> and introduced them into ATL and HTLV-1 infected cell lines using clustered regula...

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Literature Corpus work: 71fd3ace-289f-5825-9b07-42a637c9f6f1
DOI: 10.21203/rs.3.rs-6562052/v1

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